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Crhbpem1(cre)Sleep
Endonuclease-mediated Allele Detail
Summary
Symbol: Crhbpem1(cre)Sleep
Name: corticotropin releasing hormone binding protein; endonuclease-mediated mutation 1, Yu Hayashi
MGI ID: MGI:8249410
Synonyms: Crhbp-2A-Cre
Gene: Crhbp  Location: Chr13:95567884-95581339 bp, - strand  Genetic Position: Chr13, 49.5 cM
Alliance: Crhbpem1(cre)Sleep page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Recombinase)
Mutation:    Insertion
 
Crhbpem1(cre)Sleep expression driven by 1 gene
 
Mutation details: CRISPR/Cas9 genome editing technology was used to insert a P2A-Cre-pA cassette immediately before the stop codon of the gene. (J:372572)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Crhbp (mouse)
Summary of all recombinase alleles driven by Crhbp.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Crhbp Mutation:  25 strains or lines available
References
Original:  J:372572 Kashiwagi M, et al., A pontine-medullary loop crucial for REM sleep and its deficit in Parkinson's disease. Cell. 2024 Oct 31;187(22):6272-6289.e21
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory