Ifnb1em1(tdTomato,-cre)Stsn
Endonuclease-mediated Allele Detail
|
|
| Symbol: |
Ifnb1em1(tdTomato,-cre)Stsn |
| Name: |
interferon beta 1, fibroblast; endonuclease-mediated mutation 1, Daniel Stetson |
| MGI ID: |
MGI:8249192 |
| Synonyms: |
Ifnb1-Tomato-Cre-pA Terminator, I-TOMCAT |
| Gene: |
Ifnb1 Location: Chr4:88440262-88441011 bp, - strand Genetic Position: Chr4, 41.91 cM
|
| Alliance: |
Ifnb1em1(tdTomato,-cre)Stsn page
|
|
| Strain of Origin: |
Not Specified
|
|
| Allele Type: |
|
Endonuclease-mediated (No functional change, Recombinase, Reporter) |
| Mutation: |
|
Insertion
|
| |
|
Ifnb1em1(tdTomato,-cre)Stsn expression driven by
1 gene
Knock-in expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Ifnb1 (MGI:107657) |
|
|
| |
|
Mutation details: A construct containing a encephalomyocarditis virus (EMCV) internal ribosome entry site (IRES), the coding sequence for the TdTomato red fluorescent protein, a picornavirus T2A self-cleaving peptide, a nuclear localization sequence (NLS)-containing Cre recombinase, and a bovine growth hormone (BGH) polyadenylation (pA) sequence was targeted immediately downstream of the endogenous stop codon in ES cells using CRISPR/Cas9 genome editing technology.
(J:343796)
|
|
|
|
Activity: |
 Tissue activity of this recombinase allele
|
|
Driver:
|
Ifnb1
(mouse)
|
| |
|
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
| Carrying any Ifnb1 Mutation: |
20 strains or lines available
|
|
| Original: |
J:343796 Kotov DI, et al., Early cellular mechanisms of type I interferon-driven susceptibility to tuberculosis. Cell. 2023 Nov 18; |
| All: |
2 reference(s) |
|
Analysis Tools
