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Npsem1(cre)Ldl
Endonuclease-mediated Allele Detail
Summary
Symbol: Npsem1(cre)Ldl
Name: neuropeptide S; endonuclease-mediated mutation 1, Luis de Lecea
MGI ID: MGI:8249162
Synonyms: NPS-IRES-Cre
Gene: Nps  Location: Chr7:134870348-134874671 bp, + strand  Genetic Position: Chr7, 81.27 cM
Alliance: Npsem1(cre)Ldl page
Mutation
origin
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Endonuclease-mediated (Recombinase)
Mutation:    Insertion
 
Npsem1(cre)Ldl expression driven by 1 gene
 
Mutation details: CRISPR/Cas9 genome editing internal ribosomal entry sequence (IRES) linked to Cre recombinase was inserted immediately downstream of the TGA stop codon in exon 3 of the gene. (J:355278)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Nps (mouse)
Summary of all recombinase alleles driven by Nps.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nps Mutation:  15 strains or lines available
References
Original:  J:355278 Angelakos CC, et al., A cluster of neuropeptide S neurons regulates breathing and arousal. Curr Biol. 2023 Dec 18;33(24):5439-5455.e7
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory