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Dio2tm1.1(cre/ERT2)Df
Targeted Allele Detail
Summary
Symbol: Dio2tm1.1(cre/ERT2)Df
Name: deiodinase, iodothyronine, type II; targeted mutation 1, Douglas Forrest
MGI ID: MGI:8249110
Gene: Dio2  Location: Chr12:90691326-90705812 bp, - strand  Genetic Position: Chr12, 44.05 cM
Alliance: Dio2tm1.1(cre/ERT2)Df page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:365639
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout, Recombinase)
Mutation:    Insertion
 
Dio2tm1.1(cre/ERT2)Df expression driven by 1 gene
 
Mutation details: A CreERt2 cassette was fused at the ATG start codon of the endogenous gene. An frt-flanked neomycin selection cassette was removed via FLP-mediated recombination in the germline. (J:365639)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Dio2 (mouse)
Summary of all recombinase alleles driven by Dio2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dio2 Mutation:  21 strains or lines available
References
Original:  J:365639 Ng L, et al., Cochlear Fibrocyte and Osteoblast Lineages Expressing Type 2 Deiodinase Identified with a Dio2CreERt2 Allele. Endocrinology. 2021 Dec 1;162(12)
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory