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Ucp1tm1(icre)Bcgen
Targeted Allele Detail
Summary
Symbol: Ucp1tm1(icre)Bcgen
Name: uncoupling protein 1 (mitochondrial, proton carrier); targeted mutation 1, Biocytogen
MGI ID: MGI:8246898
Gene: Ucp1  Location: Chr8:84016981-84025081 bp, + strand  Genetic Position: Chr8, 39.65 cM
Alliance: Ucp1tm1(icre)Bcgen page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:351644
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Ucp1tm1(icre)Bcgen expression driven by 1 gene
 
Mutation details: The targeting construct inserted an IRES-iCre sequence cassette between the coding sequence of exon 6 and 3' UTR. Neo cassette flanked by frt sites was inserted at least 300 bp downstream of 3' UTR. (J:351644)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Ucp1 (mouse)
Summary of all recombinase alleles driven by Ucp1.
 

Expression
In Mice Carrying this Mutation: 2 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ucp1 Mutation:  50 strains or lines available
References
Original:  J:351644 Wang T, et al., Whitening of brown adipose tissue inhibits osteogenic differentiation via secretion of S100A8/A9. iScience. 2024 Feb 16;27(2):108857
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory