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Slc6a5tm1.1(icre)Stak
Targeted Allele Detail
Summary
Symbol: Slc6a5tm1.1(icre)Stak
Name: solute carrier family 6 (neurotransmitter transporter, glycine), member 5; targeted mutation 1.1, Takeshi Sakurai
MGI ID: MGI:8244918
Synonyms: GlyT2-iCre
Gene: Slc6a5  Location: Chr7:49559894-49613604 bp, + strand  Genetic Position: Chr7, 31.71 cM, cytoband B3
Alliance: Slc6a5tm1.1(icre)Stak page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:353999
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Null/knockout, Recombinase)
Mutation:    Insertion
 
Slc6a5tm1.1(icre)Stak expression driven by 1 gene
 
Mutation details: A targeting vector was designed to insert an iCre and pgk-Neo cassette in exon 2 of the GlyT2 gene so that the endogenous GlyT2 promoter drives expression of iCre. A frt-flanked neomycin selection cassette was removed via FLP-mediated recombination in the germline. (J:353999)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Slc6a5 (mouse)
Summary of all recombinase alleles driven by Slc6a5.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc6a5 Mutation:  60 strains or lines available
References
Original:  J:353999 Uchida S, et al., A Discrete Glycinergic Neuronal Population in the Ventromedial Medulla That Induces Muscle Atonia during REM Sleep and Cataplexy in Mice. J Neurosci. 2021 Feb 17;41(7):1582-1596
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory