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Csf2tm1.1(icre)Ipw
Targeted Allele Detail
Summary
Symbol: Csf2tm1.1(icre)Ipw
Name: colony stimulating factor 2 (granulocyte-macrophage); targeted mutation 1.1, Ian P Wicks
MGI ID: MGI:8244791
Synonyms: Gr/fr
Gene: Csf2  Location: Chr11:54138097-54140493 bp, - strand  Genetic Position: Chr11, 32.13 cM
Alliance: Csf2tm1.1(icre)Ipw page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:289419
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Targeted (Null/knockout, Recombinase)
Mutation:    Insertion
 
Csf2tm1.1(icre)Ipw expression driven by 1 gene
 
Mutation details: An IRES-iCre-2A-BFP-SV40pA cassette was placed 25 bp after the STOP codon in exon 4 in the 3' untranslated region of the gene. A frtflanked Neo cassette was placed 330 bp upstream of exon 4 in an intronic sequence and was removed via FLP-mediated recombination in the germline. (J:289419)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Csf2 (mouse)
Summary of all recombinase alleles driven by Csf2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Csf2 Mutation:  26 strains or lines available
References
Original:  J:289419 Louis C, et al., NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS. J Exp Med. 2020 May 4;217(5)
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory