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Enpp6em1(cre/ERT2)Lusu
Endonuclease-mediated Allele Detail
Summary
Symbol: Enpp6em1(cre/ERT2)Lusu
Name: ectonucleotide pyrophosphatase/phosphodiesterase 6; endonuclease-mediated mutation 1, Lu Sun
MGI ID: MGI:8242756
Gene: Enpp6  Location: Chr8:47439922-47549797 bp, + strand  Genetic Position: Chr8, 26.48 cM
Alliance: Enpp6em1(cre/ERT2)Lusu page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Enpp6em1(cre/ERT2)Lusu expression driven by 1 gene
 
Mutation details: Using CRISPR/Cas9 endonuclease-mediated genome editing, a single guide RNA (5'-AGTAAAGCCTGCTTCCAACA-3') was used to introduce an internal ribosome entry site (IRES) followed by a cre/ERT2 fusion gene (Cre recombinase fused to a human estrogen receptor ligand binding domain) into the 3' UTR, immediately after the endogenous stop codon of the ectonucleotide pyrophosphatase/phosphodiesterase 6 (Enpp6) gene. (J:101977, J:371676)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Enpp6 (mouse)
Summary of all recombinase alleles driven by Enpp6.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Enpp6 Mutation:  32 strains or lines available
References
Original:  J:371676 Bhambri A, et al., Genetically Labeled Premyelinating Oligodendrocytes: Bridging Oligodendrogenesis and Neuronal Activity. bioRxiv. 2024;
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
08/05/2025
MGI 6.24 		The Jackson Laboratory