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Ptprmem1(icreERT2)Zjh
Endonuclease-mediated Allele Detail
Summary
Symbol: Ptprmem1(icreERT2)Zjh
Name: protein tyrosine phosphatase receptor type M; endonuclease-mediated mutation 1, Z Josh Huang
MGI ID: MGI:8240188
Gene: Ptprm  Location: Chr17:66973942-67661452 bp, - strand  Genetic Position: Chr17, 37.88 cM
Alliance: Ptprmem1(icreERT2)Zjh page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Ptprmem1(icreERT2)Zjh expression driven by 1 gene
 
Mutation details: Using CRISPR/Cas9 endonuclease-mediated genome editing, a single guide RNA (AGCCCGAATTCAGGTACTCC AGG) was used to introduce a T2A peptide followed by an icre/ERT2 fusion gene (codon-improved Cre recombinase fused to a human estrogen receptor ligand binding domain) into the 3' UTR, immediately after the endogenous stop codon of the protein tyrosine phosphatase receptor type M (Ptprm) gene. (J:101977)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Ptprm (mouse)
Summary of all recombinase alleles driven by Ptprm.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptprm Mutation:  58 strains or lines available
References
Original:  J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
08/05/2025
MGI 6.24 		The Jackson Laboratory