About   Help   FAQ
Wfs1em1(flpo)Zjh
Endonuclease-mediated Allele Detail
Summary
Symbol: Wfs1em1(flpo)Zjh
Name: wolframin ER transmembrane glycoprotein; endonuclease-mediated mutation 1, Z Josh Huang
MGI ID: MGI:8240169
Gene: Wfs1  Location: Chr5:37123448-37146326 bp, - strand  Genetic Position: Chr5, 19.46 cM
Alliance: Wfs1em1(flpo)Zjh page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Recombinase)
Mutation:    Insertion
 
Wfs1em1(flpo)Zjh expression driven by 1 gene
 
Mutation details: using CRISPR/Cas9 endonuclease-mediated genome editing, a single guide RNA (AGCGGCGGACGCTCCTCAGG CGG) was used to introduce a T2A peptide followed by codon-optimized flp-recombinase sequence into the 3' UTR, immediately after the endogenous stop codon of the wolframin, Wolfram syndrome 1 homolog (human) (Wfs1) gene. (J:101977)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Wfs1 (mouse)
Summary of all recombinase alleles driven by Wfs1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wfs1 Mutation:  44 strains or lines available
References
Original:  J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
08/05/2025
MGI 6.24 		The Jackson Laboratory