Ttrem2(cre/ERT2)Cya
Endonuclease-mediated Allele Detail
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| Symbol: |
Ttrem2(cre/ERT2)Cya |
| Name: |
transthyretin; endonuclease-mediated mutation 2, Cyagen Biosciences |
| MGI ID: |
MGI:8235736 |
| Synonyms: |
Ttrem2(P2A-CreERT2) |
| Gene: |
Ttr Location: Chr18:20798337-20807378 bp, + strand Genetic Position: Chr18, 11.47 cM
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| Alliance: |
Ttrem2(cre/ERT2)Cya page
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| Allele Type: |
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Endonuclease-mediated (Inducible, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Ttrem2(cre/ERT2)Cya expression driven by
1 gene
Knock-in expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Ttr (MGI:98865) |
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Mutation details: Ttr-CreERT2 allele was generated via genome editing by replacing the TGA stop codon of the mouse gene with a P2A-CreERT2 cassette. Without tamoxifen treatment, CreERT2 recombinase primarily resides in the cytoplasm; nuclear translocation and recombination activity of CreERT2 only occur upon tamoxifen stimulation. When crossed with allele containing loxP sites, offspring are expected to undergo Cre-mediated recombination between loxP sites specifically in Ttr-positive cells following tamoxifen administration.
(J:326541)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Ttr
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Ttr Mutation: |
40 strains or lines available
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Analysis Tools
