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Ttrem2(cre/ERT2)Cya
Endonuclease-mediated Allele Detail
Summary
Symbol: Ttrem2(cre/ERT2)Cya
Name: transthyretin; endonuclease-mediated mutation 2, Cyagen Biosciences
MGI ID: MGI:8235736
Synonyms: Ttrem2(P2A-CreERT2)
Gene: Ttr  Location: Chr18:20798337-20807378 bp, + strand  Genetic Position: Chr18, 11.47 cM
Alliance: Ttrem2(cre/ERT2)Cya page
Mutation
origin
Strain of Origin:  C57BL/6JCya
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Ttrem2(cre/ERT2)Cya expression driven by 1 gene
 
Mutation detailsTtr-CreERT2 allele was generated via genome editing by replacing the TGA stop codon of the mouse gene with a P2A-CreERT2 cassette. Without tamoxifen treatment, CreERT2 recombinase primarily resides in the cytoplasm; nuclear translocation and recombination activity of CreERT2 only occur upon tamoxifen stimulation. When crossed with allele containing loxP sites, offspring are expected to undergo Cre-mediated recombination between loxP sites specifically in Ttr-positive cells following tamoxifen administration. (J:326541)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Ttr (mouse)
Summary of all recombinase alleles driven by Ttr.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ttr Mutation:  39 strains or lines available
References
Original:  J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/29/2025
MGI 6.24
The Jackson Laboratory