Ntrk1em2(cre/ERT2)Cya
Endonuclease-mediated Allele Detail
|
Symbol: |
Ntrk1em2(cre/ERT2)Cya |
Name: |
neurotrophic tyrosine kinase, receptor, type 1; endonuclease-mediated mutation 2, Cyagen Biosciences |
MGI ID: |
MGI:8235667 |
Synonyms: |
Ntrk1em1(IRES-CreERT2) |
Gene: |
Ntrk1 Location: Chr3:87685551-87702469 bp, - strand Genetic Position: Chr3, 38.62 cM
|
Alliance: |
Ntrk1em2(cre/ERT2)Cya page
|
|
|
Allele Type: |
|
Endonuclease-mediated (Inducible, Recombinase) |
Inducer: |
|
tamoxifen |
Mutation: |
|
Insertion
|
|
|
Ntrk1em2(cre/ERT2)Cya expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Ntrk1 (MGI:97383) |
|
|
|
|
Mutation details: This allele was generated by inserting an IRES-CreERT2 cassette via genome editing immediately downstream of the TAG stop codon in the mouse gene. Without tamoxifen treatment, CreERT2 recombinase primarily resides in the cytoplasm; nuclear translocation and recombination activity of CreERT2 only occur upon tamoxifen stimulation. When crossed with allele containing loxP sites, offspring are expected to exhibit Cre-mediated recombination between loxP sites in Ntrk1-positive cells following tamoxifen administration.
(J:326541)
|
|
|
Activity: |
 Tissue activity of this recombinase allele
|
Driver:
|
Ntrk1
(mouse)
|
|
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Ntrk1 Mutation: |
58 strains or lines available
|
|
|