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Csf2em1(icre)Ctmb
Endonuclease-mediated Allele Detail
Summary
Symbol: Csf2em1(icre)Ctmb
Name: colony stimulating factor 2 (granulocyte-macrophage); endonuclease-mediated mutation 1, Pawel Pelczar, Center for Transgenic Models
MGI ID: MGI:8235070
Synonyms: Csf2-iCre-EGFP, FROG
Gene: Csf2  Location: Chr11:54138097-54140493 bp, - strand  Genetic Position: Chr11, 32.13 cM
Alliance: Csf2em1(icre)Ctmb page
Mutation
origin
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout, Recombinase, Reporter)
Mutation:    Insertion
 
Csf2em1(icre)Ctmb expression driven by 1 gene
 
Mutation details: Using CRISPR/Cas9 genome editing technology, iCre-recombinase and an EGFP gene linked with an IRES sequence were inserted into exon 1 after the initiation ATG codon. iCre recombinase and EGFP are co-expressed under the control of the endogenous Csf2 promoter. (J:278419)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Csf2 (mouse)
Summary of all recombinase alleles driven by Csf2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Csf2 Mutation:  26 strains or lines available
References
Original:  J:278419 Komuczki J, et al., Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1beta. Immunity. 2019 May 21;50(5):1289-1304.e6
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
07/29/2025
MGI 6.24 		The Jackson Laboratory