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Brs3em1(flpo)Rei
Endonuclease-mediated Allele Detail
Summary
Symbol: Brs3em1(flpo)Rei
Name: bombesin-like receptor 3; endonuclease-mediated mutation 1, Marc L Reitman
MGI ID: MGI:8234708
Synonyms: Brs3-FlpO, Brs3-T2A-FlpO
Gene: Brs3  Location: ChrX:56088434-56094118 bp, + strand  Genetic Position: ChrX, 30.78 cM, cytoband A7.1-A7.2
Alliance: Brs3em1(flpo)Rei page
Mutation
origin
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Endonuclease-mediated (Recombinase)
Mutation:    Insertion
 
Brs3em1(flpo)Rei expression driven by 1 gene
 
Mutation details: With a Gly-Ser-Gly (GGAAGCGGA) linker, 54-base pair (bp) T2A sequence and 1,299-bp FlpO sequence were inserted into the Brs3 stop codon using CRISPR technology. Two synonymous mutations (Ala392, GCC to GCA; Glu396, GAG to GAA) were also introduced for CRISPR. (J:370608)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Brs3 (mouse)
Summary of all recombinase alleles driven by Brs3.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Brs3 Mutation:  14 strains or lines available
References
Original:  J:370608 Alcantara IC, et al., A hypothalamic circuit that modulates feeding and parenting behaviours. Nature. 2025 Jul 30;
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
08/05/2025
MGI 6.24 		The Jackson Laboratory