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Tg(Sost-cre/ERT2)2Bwd
Transgene Detail
Summary
Symbol: Tg(Sost-cre/ERT2)2Bwd
Name: transgene insertion 2, Lynda Bonewald
MGI ID: MGI:8224283
Transgene: Tg(Sost-cre/ERT2)2Bwd  Location: unknown  
Alliance: Tg(Sost-cre/ERT2)2Bwd page
Transgene
origin
Strain of Origin:  C57BL/6N
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(Sost-cre/ERT2)2Bwd expression driven by 1 gene
 
Mutation details: Usinga mouse RP24-178J4 BAC (157Kb) containing the Sost gene, recombineering was used to replace the ATG region of Sost with a Cre/ERT2 cassette. This construct was then used to generate transgenic mice. Of four lines generated, only line #2 showed strong and consistent Cre recombination in osteocytes following tamoxifen treatment and was analyzed futher. (J:361884)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Sost (mouse)
Summary of all recombinase alleles driven by Sost.
 

Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:361884 Maurel DB, et al., Characterization of a novel murine Sost ER(T2) Cre model targeting osteocytes. Bone Res. 2019;7:6
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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08/05/2025
MGI 6.24 		The Jackson Laboratory