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Mcpt8tm2.1(icre)Hkar
Targeted Allele Detail
Summary
Symbol: Mcpt8tm2.1(icre)Hkar
Name: mast cell protease 8; targeted mutation 2.1, Hajime Karasuyama
MGI ID: MGI:8224280
Synonyms: Mcpt8iCre
Gene: Mcpt8  Location: Chr14:56319623-56322730 bp, - strand  Genetic Position: Chr14, 28.19 cM
Alliance: Mcpt8tm2.1(icre)Hkar page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:269288
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout, Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Mcpt8tm2.1(icre)Hkar expression driven by 1 gene
 
Mutation details: The first exon of the gene was replaced with improved Cre (iCre) and an frt-flanked neomycin-resistance expression cassette (Neor). The selection cassette was removed via FLP-mediated recombination in the germline. (J:269288)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Mcpt8 (mouse)
Summary of all recombinase alleles driven by Mcpt8.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mcpt8 Mutation:  26 strains or lines available
References
Original:  J:269288 Shibata S, et al., Basophils trigger emphysema development in a murine model of COPD through IL-4-mediated generation of MMP-12-producing macrophages. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):13057-13062
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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07/29/2025
MGI 6.24 		The Jackson Laboratory