About   Help   FAQ
Vwftm7(cre/ERT2)Aird
Targeted Allele Detail
Summary
Symbol: Vwftm7(cre/ERT2)Aird
Name: Von Willebrand factor; targeted mutation 7, William C Aird
MGI ID: MGI:8224269
Synonyms: vWF CreERT2
Gene: Vwf  Location: Chr6:125529911-125663642 bp, + strand  Genetic Position: Chr6, 59.32 cM
Alliance: Vwftm7(cre/ERT2)Aird page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:235893
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout, Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Vwftm7(cre/ERT2)Aird expression driven by 1 gene
 
Mutation details: The tamoxifen-inducible cre gene sequence was insertion between the end of exon 1 and nucleotide 4253 of intron 3 of the mouse Vfw gene in a BAC clone from C57BL/6 BAC library RPCI-24. Correctly targeted mice express cre/ERT2 recombinase under the control of the endogenous gene regulatory elements. (J:235893)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Vwf (mouse)
Summary of all recombinase alleles driven by Vwf.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vwf Mutation:  137 strains or lines available
References
Original:  J:235893 Yuan L, et al., A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity. Nat Commun. 2016 Jan 08;7:10160
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
08/05/2025
MGI 6.24 		The Jackson Laboratory