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Vwftm7(cre/ERT2)Aird
Targeted Allele Detail
Summary
Symbol: Vwftm7(cre/ERT2)Aird
Name: Von Willebrand factor; targeted mutation 7, William C Aird
MGI ID: MGI:8224269
Synonyms: vWF CreERT2
Gene: Vwf  Location: Chr6:125529911-125663642 bp, + strand  Genetic Position: Chr6, 59.32 cM
Alliance: Vwftm7(cre/ERT2)Aird page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:235893
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout, Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Vwftm7(cre/ERT2)Aird expression driven by 1 gene
 
Mutation details: The tamoxifen-inducible cre gene sequence was insertion between the end of exon 1 and nucleotide 4253 of intron 3 of the mouse Vfw gene in a BAC clone from C57BL/6 BAC library RPCI-24. Correctly targeted mice express cre/ERT2 recombinase under the control of the endogenous gene regulatory elements. (J:235893)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Vwf (mouse)
Summary of all recombinase alleles driven by Vwf.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vwf Mutation:  137 strains or lines available
References
Original:  J:235893 Yuan L, et al., A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity. Nat Commun. 2016 Jan 08;7:10160
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
07/29/2025
MGI 6.24 		The Jackson Laboratory