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Mex3atm2.1(cre/ERT2)Ebat
Targeted Allele Detail
Summary
Symbol: Mex3atm2.1(cre/ERT2)Ebat
Name: mex3 RNA binding family member A; targeted mutation 2.1, Eduard Batlle
MGI ID: MGI:8224262
Synonyms: Mex3a-CreErt2
Gene: Mex3a  Location: Chr3:88439702-88448703 bp, + strand  Genetic Position: Chr3, 38.86 cM
Alliance: Mex3atm2.1(cre/ERT2)Ebat page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:329187
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mex3atm2.1(cre/ERT2)Ebat expression driven by 1 gene
 
Mutation details: A cassette bearing a Cre-ERT2/bGH polyA was inserted in frame with the mouse Mex3a start codon in exon 1. The neomycin cassette was removed via FLP-mediated recombination in the germline. This allele differs from Mex3atm1.1(cre/ERT2)Ebat in that no td-tomato reporter gene is included. (J:329187)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Mex3a (mouse)
Summary of all recombinase alleles driven by Mex3a.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mex3a Mutation:  26 strains or lines available
References
Original:  J:329187 Alvarez-Varela A, et al., Mex3a marks drug-tolerant persister colorectal cancer cells that mediate relapse after chemotherapy. Nat Cancer. 2022 Sep;3(9):1052-1070
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/05/2025
MGI 6.24 		The Jackson Laboratory