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Pgrem1(icre/ERT2)Fjd
Endonuclease-mediated Allele Detail
Summary
Symbol: Pgrem1(icre/ERT2)Fjd
Name: progesterone receptor; endonuclease-mediated mutation 1, Franco J DeMayo
MGI ID: MGI:8216689
Synonyms: PgriCreERT2
Gene: Pgr  Location: Chr9:8899834-8968612 bp, + strand  Genetic Position: Chr9, 2.46 cM
Alliance: Pgrem1(icre/ERT2)Fjd page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission:
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Null/knockout, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Pgrem1(icre/ERT2)Fjd expression driven by 1 gene
 
Mutation details: A single guide (sgRNA) (GCTGTTGCTCCCTACCTCGGGG) was designed to replace exon 1 of the progesterone receptor (Pgr) with a codon-improved icre/ERT2 fusion gene (an icre recombinase fused to a human estrogen receptor ligand binding domain). (J:368606)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Pgr (mouse)
Summary of all recombinase alleles driven by Pgr.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pgr Mutation:  74 strains or lines available
References
Original:  J:368606 Quiroz E, et al., A Mouse Model Engineered to Spatiotemporally Control Cre Expression in Progesterone Receptor Positive Cells. Biol Reprod. 2025 May 23;
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory