Tg(tetO-lacZ,-Gsk3b)G6Avil
Transgene Detail
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| Symbol: |
Tg(tetO-lacZ,-Gsk3b)G6Avil |
| Name: |
transgene insertion G6, J Avila |
| MGI ID: |
MGI:8209198 |
| Synonyms: |
BiTetO Betagal/GSK-3beta |
| Transgene: |
Tg(tetO-lacZ,-Gsk3b)G6Avil Location: unknown
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| Alliance: |
Tg(tetO-lacZ,-Gsk3b)G6Avil page
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| Strain of Origin: |
CBA x C57BL/6
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| Transgene Type: |
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Transgenic (Epitope tag, Inserted expressed sequence, Reporter) |
| Mutation: |
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Insertion
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Tg(tetO-lacZ,-Gsk3b)G6Avil expresses
1 gene
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Tg(tetO-lacZ,-Gsk3b)G6Avil expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| Not Specified |
tetO |
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Mutation details:
The construct consists of seven copies of the palindromic tet operator sequence flanked by two CMV promoter sequences in divergent orientations. This bi-directional promoter is followed by a Gsk3b cDNA sequence with a myc epitope at its 5'-end in one direction and beta-galactosidase (LacZ) sequence including a nuclear localization signal (NLS) in the other. Five transgenic lines were generated, and lines G6 and G7 were chosen for further analysis.
(J:67070)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:67070 Lucas JJ, et al., Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice. EMBO J. 2001 Jan 15;20(1-2):27-39 |
| All: |
9 reference(s) |
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Analysis Tools
