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Gt(ROSA)26Sorem1(CAG-tdTomato*,-cre,-EYFP, FlpO*)Ben
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sorem1(CAG-tdTomato*,-cre,-EYFP, FlpO*)Ben
Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Rui Benedito
MGI ID: MGI:8192434
Synonyms: iFlpMTomato-2A-cre/Myfp-2A-FlpO
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sorem1(CAG-tdTomato*,-cre,-EYFP, FlpO*)Ben page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:306259
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, Recombinase, Reporter)
Mutation:    Insertion
 
Gt(ROSA)26Sorem1(CAG-tdTomato*,-cre,-EYFP, FlpO*)Ben expression driven by 1 gene
 
Mutation detailsCRISPR-targeting inserted a CAG promoter, FRT F3 site, FRT 5T2 site, neomycin resistance cassette, FRT F3 site, Mb-Tomato gene (non-oligomerizing tandem-dimer DsRed fluorescent protein variant tdTomato with N-terminal 41 amino acid membrane-targeting tag sequence), 2A sequence, cre recombinase gene, WPRE, Sv40 polyadenylation sequence, FRT T2 site, MbYFP gene (monomeric enhanced yellow fluorescent protein [mYFPA206K] with N-terminal membrane-targeting tag sequence), WPRE and Sv40 polyadenylation sequence. (J:306259)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: CAG (chicken)
Summary of all recombinase alleles driven by CAG.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  1084 strains or lines available
References
Original:  J:306259 Luo W, et al., Arterialization requires the timely suppression of cell growth. Nature. 2021 Jan;589(7842):437-441
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory