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Aplnem1(flpo)Ben
Endonuclease-mediated Allele Detail
Summary
Symbol: Aplnem1(flpo)Ben
Name: apelin; endonuclease-mediated mutation 1, Rui Benedito
MGI ID: MGI:8192390
Synonyms: Apln-FlpO
Gene: Apln  Location: ChrX:47114023-47123730 bp, - strand  Genetic Position: ChrX, 25.48 cM, cytoband A3.2
Alliance: Aplnem1(flpo)Ben page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:306259
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Endonuclease-mediated (Epitope tag, Recombinase)
Mutation:    Insertion
 
Aplnem1(flpo)Ben expression driven by 1 gene
 
Mutation details: CRISPR-targeting inserted the cassette HA-NLS-FlpO-WPRE-Sv40-pA-loxP-PGK-Neo-polyA-loxP cassette (Addgene 159222) in frame with the endogenous ATG of the gene Apln. (J:306259)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Apln (mouse)
Summary of all recombinase alleles driven by Apln.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apln Mutation:  12 strains or lines available
References
Original:  J:306259 Luo W, et al., Arterialization requires the timely suppression of cell growth. Nature. 2021 Jan;589(7842):437-441
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory