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Tg(Dclk1-cre/ERT2)2Tcw
Transgene Detail
Summary
Symbol: Tg(Dclk1-cre/ERT2)2Tcw
Name: transgene insertion 2, Timothy C Wang
MGI ID: MGI:8190520
Synonyms: Dclk1-BAC-CreERT, Dclk1-CreERT
Transgene: Tg(Dclk1-cre/ERT2)2Tcw  Location: unknown  
Alliance: Tg(Dclk1-cre/ERT2)2Tcw page
Transgene
origin
Strain of Origin:  (CBA x C57BL/6J)F1
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tg(Dclk1-cre/ERT2)2Tcw expression driven by 1 gene
 
Mutation details: Using recombineering methods, the CreTM-FrtNeoFrt cassette was inserted upstream of the ATG codon in exon 2 of the Dclk1 gene in the mouse BAC clone RP23-283D6. The modified BAC construct was injected into fertilized CBA x C57BL/6J oocytes. Four founders positive for the transgene were obtained and backcrossed to C57BL/6J mice. This is line 2 with an unknown transgene copy number or genomic insertion site. (J:101977, J:209426)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Dclk1 (mouse)
Summary of all recombinase alleles driven by Dclk1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:209426 Westphalen CB, et al., Long-lived intestinal tuft cells serve as colon cancer-initiating cells. J Clin Invest. 2014 Mar 3;124(3):1283-95
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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03/18/2025
MGI 6.24 		The Jackson Laboratory