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Kremen1em1(icre)Cai
Endonuclease-mediated Allele Detail
Summary
Symbol: Kremen1em1(icre)Cai
Name: kringle containing transmembrane protein 1; endonuclease-mediated mutation 1, Huaibin Cai
MGI ID: MGI:8186449
Synonyms: Kremen12A-Cre
Gene: Kremen1  Location: Chr11:5141552-5211558 bp, - strand  Genetic Position: Chr11, 3.36 cM, cytoband A1
Alliance: Kremen1em1(icre)Cai page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Recombinase)
Mutation:    Insertion
 
Kremen1em1(icre)Cai expression driven by 1 gene
 
Mutation details: A sgRNAs (GTGGGCTTCAGTCACTCACGAGG and TGGGCTTCAGTCACTCACGAGGG) were used to target exon 9, immediately after the stop codon, of the kringle containing transmembrane protein 1 (Kremen1) gene for insertion of a 2A oligopeptide (2A) self-cleaving peptide, to mediate ribosomal skipping, fused to a codon-improved Cre recombinase sequence (icre). (J:101977, J:363792)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Kremen1 (mouse)
Summary of all recombinase alleles driven by Kremen1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kremen1 Mutation:  33 strains or lines available
References
Original:  J:363792 Dong J, et al., Molecularly distinct striatonigral neuron subtypes differentially regulate locomotion. Nat Commun. 2025 Mar 19;16(1):2710
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory