About   Help   FAQ
Cdkn2atm2(cre/ERT2)Bzsh
Targeted Allele Detail
Summary
Symbol: Cdkn2atm2(cre/ERT2)Bzsh
Name: cyclin dependent kinase inhibitor 2A; targeted mutation 2, Bin Zhou
MGI ID: MGI:8172887
Gene: Cdkn2a  Location: Chr4:89192710-89212856 bp, - strand  Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
Alliance: Cdkn2atm2(cre/ERT2)Bzsh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:364659
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  (C57BL/6 x 129S)F1
Mutation
description
Allele Type:    Targeted (Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Cdkn2atm2(cre/ERT2)Bzsh expression driven by 1 gene
 
Mutation details: A targeting vector containing the self-cleaving peptide 2A sequence and a complementary DNA (cDNA) encoding a CreERT2 fusion gene (CreERT2; Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain) followed by polyA signal, and FRT-flanked neomycin resistance cassette was inserted into the last exon of the Cdkn2a gene replacing the stop codon. (J:101977, J:364659)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Cdkn2a (mouse)
Summary of all recombinase alleles driven by Cdkn2a.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdkn2a Mutation:  66 strains or lines available
References
Original:  J:364659 Zhao H, et al., Identifying specific functional roles for senescence across cell types. Cell. 2024 Oct 1;
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory