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Spp1em1(cre)Gfng
Endonuclease-mediated Allele Detail
Summary
Symbol: Spp1em1(cre)Gfng
Name: secreted phosphoprotein 1; endonuclease-mediated mutation 1, Guoping Feng
MGI ID: MGI:8166495
Synonyms: Spp1-Cre
Gene: Spp1  Location: Chr5:104582984-104588916 bp, + strand  Genetic Position: Chr5, 50.68 cM
Alliance: Spp1em1(cre)Gfng page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Recombinase)
Mutation:    Insertion
 
Spp1em1(cre)Gfng expression driven by 1 gene
 
Mutation details: A sgRNAs (TCTGAGGTCAACTAAAGAAG and ACAAGAAAAAGTGTTAGTGA) were used to target sequences immediately before the stop codon of the secreted phosphoprotein 1 (Spp1) gene for insertion of a porcine teschovirus-1 2A oligopeptide (P2A) self-cleaving peptide, to mediate ribosomal skipping, fused to a Cre recombinase sequence (cre). (J:101977, J:361365)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Spp1 (mouse)
Summary of all recombinase alleles driven by Spp1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spp1 Mutation:  43 strains or lines available
References
Original:  J:361365 Hartley ND, et al., Distinct structural and functional connectivity of genetically segregated thalamoreticular subnetworks. Cell Rep. 2024 Dec 24;43(12):115037
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory