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Tg(ITGAM-cre/ERT2,U6-RNAi:Cacna1c)205Ttan
Transgene Detail
Summary
Symbol: Tg(ITGAM-cre/ERT2,U6-RNAi:Cacna1c)205Ttan
Name: transgene insertion 205, Tsutomu Tanabe
MGI ID: MGI:8164202
Transgene: Tg(ITGAM-cre/ERT2,U6-RNAi:Cacna1c)205Ttan  Location: unknown  
Alliance: Tg(ITGAM-cre/ERT2,U6-RNAi:Cacna1c)205Ttan page
Transgene
origin
Strain of Origin:  C57BL/6J
Transgene
description
Transgene Type:    Transgenic (Inducible, Knockdown, Recombinase)
Mutation:    Insertion
  Tg(ITGAM-cre/ERT2,U6-RNAi:Cacna1c)205Ttan involves 1 genes/genome features (Cacna1c) View all
 
Tg(ITGAM-cre/ERT2,U6-RNAi:Cacna1c)205Ttan expression driven by 1 gene
 
Mutation details: The transgene is composed of the human RNU6 promoter disrupted by a floxed neomycin resistance cassette, short-hairpin RNA targeting Cacna1c, the human GH sequence, and the human promoter driving expression of an inducible cre recombinase gene (cre/ERT2) in microglial/macrophage cells. (J:278614)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: ITGAM (human)
Summary of all recombinase alleles driven by ITGAM.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:278614 Wang X, et al., Blockade of microglial Cav1.2 Ca(2+) channel exacerbates the symptoms in a Parkinson's disease model. Sci Rep. 2019 Jun 24;9(1):9138
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory