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Gt(ROSA)26Sortm11(CAG-cre/ERT2,-flpo,-tdTomato*)Ben
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm11(CAG-cre/ERT2,-flpo,-tdTomato*)Ben
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 11, Rui Benedito
MGI ID: MGI:8161960
Synonyms: iSuRe-HadCre
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm11(CAG-cre/ERT2,-flpo,-tdTomato*)Ben page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:352091
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase, Reporter)
Mutation:    Insertion
 
Gt(ROSA)26Sortm11(CAG-cre/ERT2,-flpo,-tdTomato*)Ben expression driven by 1 gene
 
Mutation detailsThe targeting construct inserted into the locus a CAG promoter, FRT site, loxP site, triple stop codons, loxP site, cre recombinase gene,loxN site, modified estrogen receptor (ERT2), loxN site, in-frame Thosea asigna virus 2A cleavage site (T2A; mediates ribosomal skipping), flpo recombinase gene, FRT site, and the Mb-Tomato gene (non-oligomerizing tandem-dimer DsRed fluorescent protein variant tdTomato with N-terminal 41 amino acid membrane-targeting tag sequence). (J:352091)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: CAG (chicken)
Summary of all recombinase alleles driven by CAG.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  1084 strains or lines available
References
Original:  J:352091 Garcia-Gonzalez I, et al., iSuRe-HadCre is an essential tool for effective conditional genetics. Nucleic Acids Res. 2024 Jul 22;52(13):e56
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory