Lyve1<em1(cre/ERT2)Jkpns> Endonuclease-mediated Allele Detail MGI Mouse (MGI:7859688)

Lyve1^{em1(cre/ERT2)Jkpns}
Endonuclease-mediated Allele Detail

Summary

Symbol:	Lyve1^{em1(cre/ERT2)Jkpns}
Name:	lymphatic vessel endothelial hyaluronan receptor 1; endonuclease-mediated mutation 1, Jonathan Kipnis
MGI ID:	MGI:7859688
Synonyms:	Lyve1^creERT2
Gene:	Lyve1 Location: Chr7:110449814-110462160 bp, - strand Genetic Position: Chr7, 57.89 cM, cytoband F2
Alliance:	Lyve1^{em1(cre/ERT2)Jkpns} page

Mutation
origin

Strain of Origin:

C57BL/6J

Mutation
description

Allele Type:

Endonuclease-mediated (Inducible, Recombinase)

Inducer:

tamoxifen

Mutation:

Insertion

Lyve1^{em1(cre/ERT2)Jkpns} expression driven by 1 gene

Mutation details: Using CRISPR/Cas9 endonuclease-mediated genome editing, a guide RNA (GAAGTTTAGATGCAAGAGAGTGG) was used to introduce a cre/ERT2 fusion gene (a Cre recombinase fused to a human estrogen receptor ligand binding domain) fused to a P2A self-cleaving peptide immediately upstream of the 3' UTR of the lymphatic vessel endothelial hyaluronan receptor 1 (Lyve1) gene on chromosome 7. (J:101977, J:361567)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Lyve1 (mouse) Summary of all recombinase alleles driven by Lyve1. Alliance mouse Lyve1 gene page

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Lyve1 Mutation:	14 strains or lines available

References

Original:	J:361567 Du S, et al., Brain-Engrafted Monocyte-derived Macrophages from Blood and Skull-Bone Marrow Exhibit Distinct Identities from Microglia. bioRxiv. 2024;
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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