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Gene Expression Data
Assay Details
Assay
Reference: J:245876 Rohacek AM, et al., ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative Splicing that Disrupt Cochlear Development. Dev Cell. 2017 Nov 06;43(3):318-331.e5
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7857197
Gene symbol: Kcnq1
Gene name: potassium voltage-gated channel, subfamily Q, member 1
Antibody: Anti-KCNQ1 (C-20) sc-10646
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 5I: embryonic day 18.5 (more )
Structure Cell Type Level Pattern Image Note
TS26: cochlea epithelium strial marginal cell Present 5I
Specimen 5P: embryonic day 18.5; Esrp1tm1.2Rpc/Esrp1tm1.2Rpc (more )
Structure Cell Type Level Pattern Image Note
TS26: cochlea epithelium strial marginal cell Trace 5P Expression reduced compared to control.
Specimen 7D: embryonic day 18.5 (more )
Structure Cell Type Level Pattern Image Note
TS26: cochlea epithelium strial marginal cell Present 7D
Specimen 7K: embryonic day 18.5; Esrp1tm1.2Rpc/Esrp1tm1.2Rpc (more )
Structure Cell Type Level Pattern Image Note
TS26: cochlea epithelium strial marginal cell Trace 7K Dramatic reduction of strial marginal cells compared to control
Specimen 7R: embryonic day 18.5; Esrp1tm1.2Rpc/Esrp1tm1.2Rpc, Fgf9tm1b(KOMP)Wtsi/Fgf9+ (more )
Structure Cell Type Level Pattern Image Note
TS26: cochlea epithelium strial marginal cell Present 7R Authors report recovery of strial marginal cells identity.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory