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Gene Expression Data
Assay Details
Assay
Reference: J:245876 Rohacek AM, et al., ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative Splicing that Disrupt Cochlear Development. Dev Cell. 2017 Nov 06;43(3):318-331.e5
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7857194
Gene symbol: Cdh1
Gene name: cadherin 1
Antibody: Anti-E-Cadherin (610181; Clone 36)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 5A: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: cochlea epithelium Present Regionally restricted 5A Expression in lateral wall of cochlear epithelium.
Specimen 5D: embryonic day 16.5; Esrp1tm1.2Rpc/Esrp1tm1.2Rpc (more )
Structure Level Pattern Image Note
TS24: cochlea epithelium Present Regionally restricted 5D Prounounced expansion of cells with flattened epithelial morphology characteristic of Reissner's membrane, and complte absence of cuboidal-shaped marginal cells.
Specimen 5H: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: cochlea epithelium Present Regionally restricted 5H Expression in lateral wall of cochlear epithelium.
Specimen 5O: embryonic day 18.5; Esrp1tm1.2Rpc/Esrp1tm1.2Rpc (more )
Structure Level Pattern Image Note
TS26: cochlea epithelium Present Regionally restricted 5O Lateral cochlear epithelium highly dysmorphic compared to control. No morphological evidence of marginal cells.
TS26: cochlear duct Present Regionally restricted 5O Expanded and partially collapsed Reissner's membrane.
Specimen 7A: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: cochlear duct Present Regionally restricted 7A Expression in Reissner's memebrane.
Specimen 7H: embryonic day 18.5; Esrp1tm1.2Rpc/Esrp1tm1.2Rpc (more )
Structure Level Pattern Image Note
TS26: cochlear duct Present Regionally restricted 7H Expansion of Reissner's membrane.
Specimen 7O: embryonic day 18.5; Esrp1tm1.2Rpc/Esrp1tm1.2Rpc, Fgf9tm1b(KOMP)Wtsi/Fgf9+ (more )
Structure Level Pattern Image Note
TS26: cochlear duct Present Regionally restricted 7O Signficant retraction of Reissner's membrane.
Specimen S7A: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: cochlear duct Present S7A
Specimen S7B: embryonic day 18.5; Esrp1tm1.2Rpc/Esrp1tm1.2Rpc (more )
Structure Level Pattern Image Note
TS26: cochlear duct Present Regionally restricted S7B Authors report that 16% of embryos exhibit a cystic inner ear with no obvious vesticular or cochlear outgrowth.
Specimen S7C: embryonic day 18.5; Esrp1tm1.2Rpc/Esrp1tm1.2Rpc, Fgf9tm1b(KOMP)Wtsi/Fgf9+ (more )
Structure Level Pattern Image Note
TS26: cochlear duct Present Regionally restricted S7C 46% of embryos exhibit a cystic inner ear.
Specimen S7D: embryonic day 18.5; Esrp1tm1.2Rpc/Esrp1tm1.2Rpc, Fgf9tm1b(KOMP)Wtsi/Fgf9tm1b(KOMP)Wtsi (more )
Structure Level Pattern Image Note
TS26: cochlear duct Present Regionally restricted S7D All double mutants examined displayed cystic inner ears.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
MGI 6.24 		The Jackson Laboratory