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Gene Expression Data
Assay Details
Assay
Reference: J:245876 Rohacek AM, et al., ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative Splicing that Disrupt Cochlear Development. Dev Cell. 2017 Nov 06;43(3):318-331.e5
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7857188
Gene symbol: Myo7a
Gene name: myosin VIIA
Antibody: anti-myosin VIIa (#25-6790)
Detection system: Secondary antibody coupled to Alexa Fluor 594
Results
Specimen 2E: embryonic day 18.5 (more )
Note: Base of cochlea. Double labeled: red - Myo7a; green - phalloidin.
Structure Cell Type Level Pattern Image Note
TS26: cochlea epithelium cochlea auditory hair cell Present 2E
Specimen 2F: embryonic day 18.5; Esrp1tm1.2Rpc/Esrp1tm1.2Rpc (more )
Note: Base of cochlea. Double labeled: red - Myo7a; green - phalloidin.
Structure Cell Type Level Pattern Image Note
TS26: cochlea epithelium cochlea auditory hair cell Present 2F Hair cells at base and middle turn showed immature morphology compared with control.
Specimen 2G: embryonic day 18.5 (more )
Note: Mid cochlea. Double labeled: red - Myo7a; green - phalloidin.
Structure Cell Type Level Pattern Image Note
TS26: cochlea epithelium cochlea auditory hair cell Present 2G
Specimen 2H: embryonic day 18.5; Esrp1tm1.2Rpc/Esrp1tm1.2Rpc (more )
Note: Mid cochlea. Double labeled: red - Myo7a; green - phalloidin.
Structure Cell Type Level Pattern Image Note
TS26: cochlea epithelium cochlea auditory hair cell Present 2H Hair cells at base and middle turn showed immature morphology compared with control.
Specimen 2I: embryonic day 18.5 (more )
Note: Apex of cochlea. Double labeled: red - Myo7a; green - phalloidin.
Structure Cell Type Level Pattern Image Note
TS26: cochlea epithelium cochlea auditory hair cell Present 2I
Specimen 2J: embryonic day 18.5; Esrp1tm1.2Rpc/Esrp1tm1.2Rpc (more )
Note: Apex of cochlea. Double labeled: red - Myo7a; green - phalloidin.
Structure Cell Type Level Pattern Image Note
TS26: cochlea epithelium cochlea auditory hair cell Trace Regionally restricted 2J 25% decrease in total cochlear hair cell number primarily accounted for by near complete absence of hair cells at apex of cochlear duct.
Specimen 2N: postnatal day 0 (more )
Note: Base of cochlea. Double labeled: red - Myo7a; green - phalloidin.
Structure Cell Type Level Pattern Image Note
TS27: cochlea epithelium cochlea auditory hair cell Present 2N
Specimen 2O: postnatal day 0; Esrp1tm1.2Rpc/Esrp1tm1.2Rpc (more )
Note: Base of cochlea. Double labeled: red - Myo7a; green - phalloidin.
Structure Cell Type Level Pattern Image Note
TS27: cochlea epithelium cochlea auditory hair cell Present 2O air cell morphology at base and middle turns more advanced than at E18.5. Notable improvement in sterocilia morphology comparable with control.
Specimen 2P: postnatal day 0 (more )
Note: Mid cochlea. Double labeled: red - Myo7a; green - phalloidin.
Structure Cell Type Level Pattern Image Note
TS27: cochlea epithelium cochlea auditory hair cell Present 2P
Specimen 2Q: postnatal day 0; Esrp1tm1.2Rpc/Esrp1tm1.2Rpc (more )
Note: Mid cochlea. Double labeled: red - Myo7a; green - phalloidin.
Structure Level Pattern Image Note
TS27: cochlea epithelium Present 2Q Hair cell morphology at base and middle turns more advanced than at E18.5. Notable improvement in sterocilia morphology comparable with control.
Specimen 2R: postnatal day 0 (more )
Note: Apex of cochlea. Double labeled: red - Myo7a; green - phalloidin.
Structure Cell Type Level Pattern Image Note
TS27: cochlea epithelium cochlea auditory hair cell Present 2R
Specimen 2S: postnatal day 0; Esrp1tm1.2Rpc/Esrp1tm1.2Rpc (more )
Note: Apex of cochlea. Double labeled: red - Myo7a; green - phalloidin.
Structure Cell Type Level Pattern Image Note
TS27: cochlea epithelium cochlea auditory hair cell Trace Regionally restricted 2S 25% decrease in total cochlear hair cell number primarily accounted for by near complete absense of hair cells at apex.
Specimen S3A: embryonic day 18.5 (more )
Note: Apical turn.
Structure Cell Type Level Pattern Image Note
TS26: cochlear duct cochlea auditory hair cell Present S3A
Specimen S3B: embryonic day 18.5; Esrp1tm1.2Rpc/Esrp1tm1.2Rpc (more )
Note: Apical turn.
Structure Cell Type Level Pattern Image Note
TS26: cochlear duct cochlea auditory hair cell Trace Regionally restricted S3B Near complete absence of hair cells at apex of cochlear duct.
Specimen S3C: postnatal day 0 (more )
Note: Apical turn.
Structure Cell Type Level Pattern Image Note
TS27: cochlear duct cochlea auditory hair cell Present S3C
Specimen S3D: postnatal day 0; Esrp1tm1.2Rpc/Esrp1tm1.2Rpc (more )
Note: Apical turn.
Structure Cell Type Level Pattern Image Note
TS27: cochlear duct cochlea auditory hair cell Present S3D Expression in some hair cells at apex, in absence of further elongation of duct.
Specimen S4A: embryonic day 18.5 (more )
Note: Apex of cochlea. Double labeled: red - Myo7a; green - Sox2 (assay MGI:7857189).
Structure Cell Type Level Pattern Image Note
TS26: cochlea cochlea auditory hair cell Present S4A
Specimen S4B: embryonic day 18.5; Esrp1tm1.2Rpc/Esrp1tm1.2Rpc (more )
Note: Apex of cochlea. Double labeled: red - Myo7a; green - Sox2 (assay MGI:7857189).
Structure Level Pattern Image Note
TS26: cochlea Trace Regionally restricted S4B Near complete absence of hair cells at apex of cochlear duct.
Specimen S4D: embryonic day 18.5 (more )
Note: Base of cochlea. Double labeled: red - Myo7a; green - Sox2 (assay MGI:7857189).
Structure Cell Type Level Pattern Image Note
TS26: cochlea cochlea auditory hair cell Present S4D
Specimen S4E: embryonic day 18.5; Esrp1tm1.2Rpc/Esrp1tm1.2Rpc (more )
Note: Base of cochlea. Double labeled: red - Myo7a; green - Sox2 (assay MGI:7857189).
Structure Cell Type Level Pattern Image Note
TS26: cochlea cochlea auditory hair cell Present Regionally restricted S4E Expression in some hair cells at apex, in absence of further elongation of duct.
Specimen S4J: embryonic day 18.5 (more )
Note: Double labeled: red - Myo7a; green - Nefm (assay MGI:7857191).
Structure Cell Type Level Pattern Image Note
TS26: crista ampullaris vestibular hair cell Present S4J
Specimen S4K: embryonic day 18.5; Esrp1tm1.2Rpc/Esrp1tm1.2Rpc (more )
Note: Double labeled: red - Myo7a; green - Nefm (assay MGI:7857191).
Structure Cell Type Level Pattern Image Note
TS26: crista ampullaris vestibular hair cell Present Regionally restricted S4K Only slight alterations in vestibular sensory structures (maculae and cristae) compared to control.
Specimen 4S/U: postnatal day 0 (more )
Note: Double labeled: red - Myo7a; green - Sox2 (assay MGI:7857189).
Structure Cell Type Level Pattern Image Note
TS27: organ of Corti cochlea auditory hair cell Present 4U , 4S
Specimen 4V/X: postnatal day 0; Esrp1tm1.2Rpc/Esrp1tm1.2Rpc (more )
Note: Double labeled: red - Myo7a; green - Sox2 (assay MGI:7857189).
Structure Cell Type Level Pattern Image Note
TS27: organ of Corti cochlea auditory hair cell Present 4X , 4V
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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