Gata3<em1(flpo)Good> Endonuclease-mediated Allele Detail MGI Mouse (MGI:7855857)

Gata3^{em1(flpo)Good}
Endonuclease-mediated Allele Detail

Summary

Symbol:	Gata3^{em1(flpo)Good}
Name:	GATA binding protein 3; endonuclease-mediated mutation 1, Lisa Goodrich
MGI ID:	MGI:7855857
Synonyms:	Gata3-FlpO
Gene:	Gata3 Location: Chr2:9861889-9894845 bp, - strand Genetic Position: Chr2, 6.69 cM
Alliance:	Gata3^{em1(flpo)Good} page

Mutation
origin

Strain of Origin:

C57BL/6J

Mutation
description

Allele Type:

Endonuclease-mediated (Recombinase)

Mutation:

Insertion

Gata3^{em1(flpo)Good} expression driven by 1 gene

Mutation details: CRISPR-Cas9 was used to insert a T2A-FlpO construct upstream of the endogenous stop codon. Additional mutations include: Gata3 NM_001417051: c.1375G>T (c.*43G>T in the Gata3 3 UTR); FlpO: c.35C>A (p.Glu12Lys); Flpo:g.387G>A (p.Val129Val). (J:361089)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gata3 (mouse) Summary of all recombinase alleles driven by Gata3. Alliance mouse Gata3 gene page

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Gata3 Mutation:	32 strains or lines available

References

Original:	J:361089 Sitko AA, et al., Lateral olivocochlear neurons modulate cochlear responses to noise exposure. Proc Natl Acad Sci U S A. 2025;122(4):e2404558122
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24