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Gene Expression Data
Assay Details
Assay
Reference: J:175083 Lorenz A, et al., Severe alterations of cerebellar cortical development after constitutive activation of wnt signaling in granule neuron precursors. Mol Cell Biol. 2011 Aug;31(16):3326-38
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7852355
Gene symbol: Ctnnb1
Gene name: catenin beta 1
Antibody: anti-beta-catenin (clone 14) (#610153)
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase
Results
Specimen 2A: postnatal day 21; Apctm1Rsmi/Apc+, Tg(Atoh1-cre/Esr1*)14Fsh/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: cerebellum molecular layer Present 2A No nuclear expression.
Specimen 2B: postnatal day 21; Apctm1Rsmi/Apctm1Rsmi, Tg(Atoh1-cre/Esr1*)14Fsh/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: cerebellum molecular layer Present 2B Ectopic cell clusters in the mutant showed no nuclear expression.
Specimen 3E: embryonic day 16.5; Apctm1Rsmi/Apc+, Tg(Atoh1-cre/Esr1*)14Fsh/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: cerebellum external granule cell layer Present 3E With no nuclear expression.
Specimen 3G: embryonic day 16.5; Apctm1Rsmi/Apctm1Rsmi, Tg(Atoh1-cre/Esr1*)14Fsh/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: cerebellum external granule cell layer Present 3G With no nuclear expression, similar as in the control.
Specimen 3M: postnatal day 0; Apctm1Rsmi/Apc+, Tg(Atoh1-cre/Esr1*)14Fsh/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: cerebellum external granule cell layer Present 3M With no nuclear expression.
Specimen 3O: postnatal day 0; Apctm1Rsmi/Apctm1Rsmi, Tg(Atoh1-cre/Esr1*)14Fsh/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: cerebellum external granule cell layer Present 3O Expression was found in the nuclei.
Specimen 4D: postnatal day 3; Apctm1Rsmi/Apc+, Tg(Atoh1-cre/Esr1*)14Fsh/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: cerebellum external granule cell layer Present 4D About 4% displayed a nuclear accumulation.
Specimen 4E: postnatal day 3; Apctm1Rsmi/Apctm1Rsmi, Tg(Atoh1-cre/Esr1*)14Fsh/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: cerebellum external granule cell layer Present 4E About 20% displayed a nuclear accumulation, compared with 4% in controls.
Specimen 4J: postnatal day 7; Apctm1Rsmi/Apc+, Tg(Atoh1-cre/Esr1*)14Fsh/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: cerebellum external granule cell layer Present 4J Low percentage of cells displayed a nuclear accumulation.
Specimen 4K: postnatal day 7; Apctm1Rsmi/Apctm1Rsmi, Tg(Atoh1-cre/Esr1*)14Fsh/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: cerebellum external granule cell layer Present 4K Nuclear accumulation was present in significantly more cells than in control granule cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/24/2026
MGI 6.24 		The Jackson Laboratory