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Tg(CAG-LacZ,-ACVR1*,-EGFP)A11Mis
Transgene Detail
Summary
Symbol: Tg(CAG-LacZ,-ACVR1*,-EGFP)A11Mis
Name: transgene insertion A11, Yuji Mishina
MGI ID: MGI:7840390
Synonyms: Tg(CAG-LacZ,-ACVR1*,-EGFP)2Mis
Transgene: Tg(CAG-LacZ,-ACVR1*,-EGFP)A11Mis  Location: unknown  
Alliance: Tg(CAG-LacZ,-ACVR1*,-EGFP)A11Mis page
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe modified chicken beta-actin promoter (CAG) was used to drive ubiquitous expression of a floxed LacZ gene with a triple polyadenylation signal sequence followed by a constitutively active human ACVR1 sequence with the amino acid substitution of glutamine with aspartic acid at position 207 (Q207D), an IRES sequence, and the EGFP coding sequence and a poly(A) signal. (J:304330)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:304330 Yang J, et al., Generation of a new mouse line with conditionally activated signaling through the BMP receptor, ACVR1: A tool to characterize pleiotropic roles of BMP functions. Genesis. 2021 Apr 14;:e23419
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory