Tg(CD2-TcraTrav16,H2-K1-TcrbTrbv5)R161HRrc
Transgene Detail
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| Symbol: |
Tg(CD2-TcraTrav16,H2-K1-TcrbTrbv5)R161HRrc |
| Name: |
transgene insertion R161H, Rachel R Caspi |
| MGI ID: |
MGI:7790611 |
| Synonyms: |
R161H |
| Transgene: |
Tg(CD2-TcraTrav16,H2-K1-TcrbTrbv5)R161HRrc Location: unknown
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| Alliance: |
Tg(CD2-TcraTrav16,H2-K1-TcrbTrbv5)R161HRrc page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Mutation details: The transgene contains, TCR and chains were cloned from a highly uveitogenic T cell line, specific to the IRBP161180 sequence, which encodes a major pathogenic epitope for B10.RIII mice, a strain highly susceptible to experimental autoimmune uveitis (EAU). The TCR a and b sequences were placed under control of the promoter and locus control region of the human CD2 gene, and the mouse H-2K promoter, respectively. This is high expressing line R161H having 5 TCR a and 8 TCR b tandem copies of the transgene inserted into the chromosome 9.
(J:296287)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:296287 Horai R, et al., Breakdown of immune privilege and spontaneous autoimmunity in mice expressing a transgenic T cell receptor specific for a retinal autoantigen. J Autoimmun. 2013 Aug;44:21-33 |
| All: |
7 reference(s) |
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Analysis Tools
