About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:174095 Cai Z, et al., Loss of shp2-mediated mitogen-activated protein kinase signaling in muller glial cells results in retinal degeneration. Mol Cell Biol. 2011 Jul;31(14):2973-83
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7788477
Gene symbol: Stat3
Gene name: signal transducer and activator of transcription 3
Antibody: anti-phospho-STAT3 (D3A7) (#9145)
Assay notes: The antibody used recognizes the phosphorylated form of the protein.
Results
Specimen 3C WT: postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: retina Absent 3C WT
Specimen 3C cKO: postnatal day 21; Ptpn11tm1Gsf/Ptpn11tm1Gsf, Tg(Six3-cre)69Frty/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS28: retina photoreceptor cell Present Scattered 3C cKO Mostly observed in the disorganized photoreceptors.
Specimen 4F: postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: retina Absent 4F
Specimen 4G: postnatal day 21; Ptpn11tm1Gsf/Ptpn11tm1Gsf, Tg(Six3-cre)69Frty/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: retina layer Present Scattered 4G Mostly observed in the disorganized photoreceptors.
Specimen 4H: postnatal day 21; Stat3tm1Xyfu/Stat3tm1Xyfu, Tg(Six3-cre)69Frty/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: retina Absent 4H Similar as in the wild-type.
Specimen 4I: postnatal day 21; Ptpn11tm1Gsf/Ptpn11tm1Gsf, Stat3tm1Xyfu/Stat3tm1Xyfu, Tg(Six3-cre)69Frty/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: retina Absent 4I Retina was even thinner than that of Shp2-cKO.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory