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Gene Expression Data
Assay Details
Assay
Reference: J:305429 Kaiser M, et al., Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse. Development. 2021 Apr 15;148(8):dev195651
Assay type: RNA in situ
MGI Accession ID: MGI:7788390
Gene symbol: Neurod1
Gene name: neurogenic differentiation 1
Probe: Neurod1 probe
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 6A anterior control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted 6A anterior control Neurod1 Expression was found in the anterior ventro-lateral otocyst.
TS17: acoustic ganglion Present Regionally restricted 6A anterior control Neurod1 Expression was found in the periphery of the statoacoustic ganglion.
Specimen 6A anterior Tbx2/3cDKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted 6A anterior Tbx2/3cDKO Neurod1 In Tbx2/3cDKO otocysts, expression was expanded posterior-ventrally into the non-neurogenic region of the otocysts, and was also observed in cells underneath the epithelium.
Specimen 6A mid-transverse control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Ambiguous 6A mid-transverse control Neurod1 Expression was found in the anterior ventro-lateral otocyst.
Specimen 6A mid-transverse Tbx2/3cDKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted 6A mid-transverse Tbx2/3cDKO Neurod1 In Tbx2/3cDKO otocysts, expression was expanded posterior-ventrally into the non-neurogenic region of the otocysts, and was also observed in cells underneath the epithelium.
Specimen 6A posterior control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Ambiguous 6A posterior control Neurod1 Expression was found in the anterior ventro-lateral otocyst.
Specimen 6A posterior Tbx2/3cDKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted 6A posterior Tbx2/3cDKO Neurod1 In Tbx2/3cDKO otocysts, expression was expanded posterior-ventrally into the non-neurogenic region of the otocysts, and was also observed in cells underneath the epithelium.
Specimen S5A anterior control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Present S5A anterior control Neurod1
Specimen S5A anterior Tbx2cKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present S5A anterior Tbx2cKO Neurod1 Posterior expansion of the neurogenic domain occurred in Tbx2cKO otocyst.
Specimen S5A mid-transverse control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Present S5A mid-transverse control Neurod1
Specimen S5A mid-transverse Tbx2cKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present S5A mid-transverse Tbx2cKO Neurod1 Posterior expansion of the neurogenic domain occurred in Tbx2cKO otocyst.
Specimen S5A posterior control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Ambiguous S5A posterior control Neurod1
Specimen S5A posterior Tbx2cKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present S5A posterior Tbx2cKO Neurod1 Posterior expansion of the neurogenic domain occurred in Tbx2cKO otocyst.
Specimen S5B anterior control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Present S5B anterior control Neurod1
Specimen S5B anterior Tbx3cKO: embryonic day 10.5; Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present S5B anterior Tbx3cKO Neurod1 Posterior expansion of the neurogenic domain did not occur in the Tbx3cKO otocysts.
Specimen S5B mid-transverse control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Present S5B mid-transverse control Neurod1
Specimen S5B mid-transverse Tbx3cKO: embryonic day 10.5; Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Present S5B mid-transverse Tbx3cKO Neurod1 Posterior expansion of the neurogenic domain did not occur in the Tbx3cKO otocysts.
Specimen S5B posterior control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Ambiguous S5B posterior control Neurod1
Specimen S5B posterior Tbx3cKO: embryonic day 10.5; Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: otocyst Ambiguous S5B posterior Tbx3cKO Neurod1 Posterior expansion of the neurogenic domain did not occur in the Tbx3cKO otocysts.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory