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Gene Expression Data
Assay Details
Assay
Reference: J:305429 Kaiser M, et al., Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse. Development. 2021 Apr 15;148(8):dev195651
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7788200
Gene symbol: Tbx3
Gene name: T-box 3
Antibody: Anti-Tbx3 (E-20); sc-31656
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to rhodamine
Results
Specimen 1D E9.5: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: otocyst Present Regionally restricted 1D Tbx3 E9.5 Expression started at E9.5 in the lateral otocyst.
Specimen 1D E10.5: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted 1D Tbx3 E10.5 From E10.5 onwards, expression was confined to the lateral aspects of the developing vestibular system and ventro-medially to the epithelium of the cochlear duct.
Specimen 1D E11.5: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: otocyst Present Regionally restricted 1D Tbx3 E11.5 Expression was detected ventro-medially in the epithelium of the cochlear duct.
TS19: inner ear vestibular component Present Regionally restricted 1D Tbx3 E11.5 Expression was detected in the lateral aspects of the developing vestibular system.
Specimen 1D E12.0: embryonic day 12.0 (more )
Structure Level Pattern Image Note
TS20: cochlear duct epithelium Present Regionally restricted 1D Tbx3 E12.0 Expression was detected ventro-medially in the epithelium of the cochlear duct.
TS20: inner ear vestibular component Present Regionally restricted 1D Tbx3 E12.0 Expression was detected in the lateral aspects of the developing vestibular system.
Specimen S1B E9.5 control: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: otocyst epithelium Present S1B TBX3 E9.5 control
Specimen S1B E9.5 Tbx2/3cDKO: embryonic day 9.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: otocyst epithelium Absent S1B TBX3 E9.5 Tbx2/3cDKO
Specimen S1B E10.5 control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst epithelium Present S1B TBX3 E10.5 control
TS17: acoustic ganglion Present Regionally restricted S1B TBX3 E10.5 control A subset of cells were positively stained.
Specimen S1B E10.5 Tbx2/3cDKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: acoustic ganglion Absent S1B TBX3 E10.5 Tbx2/3cDKO
TS17: otocyst epithelium Absent S1B TBX3 E10.5 Tbx2/3cDKO
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory