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Gene Expression Data
Assay Details
Assay
Reference: J:305429 Kaiser M, et al., Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse. Development. 2021 Apr 15;148(8):dev195651
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7788199
Gene symbol: Tbx2
Gene name: T-box 2
Antibody: Anti-TBX2 (07-318)
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to rhodamine
Results
Specimen 1D E9.5: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: otocyst epithelium Present Regionally restricted 1D Tbx2 E9.5 At E9.5, Tbx2 was expressed in the epithelium of the entire otocyst with exception of the dorsolateral quadrant.
Specimen 1D E10.5: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst Present Regionally restricted 1D Tbx2 E10.5 Expression was found ventrally in the developing cochlear duct, dorso-medially in the endolymphatic duct and in the central region, the vestibule, but not in the dorso-lateral region.
Specimen 1D E11.5: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: otocyst Present Regionally restricted 1D Tbx2 E11.5 Expression was found ventrally in the developing cochlear duct, dorso-medially in the endolymphatic duct and in the central region, the vestibule, but not in the dorso-lateral region.
Specimen 1D E12.0: embryonic day 12.0 (more )
Structure Level Pattern Image Note
TS20: cochlear duct Present Regionally restricted 1D Tbx2 E12.0 Expression was found ventrally in the cochlear duct.
TS20: inner ear Present Regionally restricted 1D Tbx2 E12.0 Expression was detected dorso-medially in the endolymphatic duct and in the central region, the vestibule, but not in the dorso-lateral region.
TS20: inner ear vestibular component Present 1D Tbx2 E12.0
Specimen S1B E9.5 control: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: otocyst epithelium Present S1B TBX2 E9.5 control
Specimen S1B E9.5 Tbx2/3cDKO: embryonic day 9.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: otocyst epithelium Absent S1B TBX2 E9.5 Tbx2/3cDKO
Specimen S1B E10.5 control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: otocyst epithelium Present S1B TBX2 E10.5 control
TS17: acoustic ganglion Present Regionally restricted S1B TBX2 E10.5 control A subset of cells were positively stained.
Specimen S1B E10.5 Tbx2/3cDKO: embryonic day 10.5; Tbx2tm2.1Vmc/Tbx2tm2.1Vmc, Tbx3tm1Pa/Tbx3tm1Pa, Tg(Pax2-cre)10Shwl/0, Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: acoustic ganglion Absent S1B TBX2 E10.5 Tbx2/3cDKO
TS17: otocyst epithelium Absent S1B TBX2 E10.5 Tbx2/3cDKO
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory