Opn1sw RNA in situ Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:153683 Jia L, et al., Retinoid-related orphan nuclear receptor RORbeta is an early-acting factor in rod photoreceptor development. Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17534-9
Assay type:	RNA in situ
MGI Accession ID:	MGI:7782364
Gene symbol:	Opn1sw
Gene name:	opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)

Probe:	mS opsin probe
Probe preparation:	Antisense labelled with digoxigenin RNA
Visualized with:	Alkaline phosphatase

Results

1A S opsin +/+ (sup) ©

Specimen 1A S opsin +/+ (sup): postnatal day 23 (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: retina outer nuclear layer	retinal cone cell	Trace	Regionally restricted	1A S opsin +/+ (sup)	Expression in cones at outer edge of outer nuclear layer.

1A S opsin -/- (sup) ©

Specimen 1A S opsin -/- (sup): postnatal day 23; Rorb^tm1Mba/Rorb^tm1Mba (more

)

Structure	Level	Pattern	Image	Note
TS28: retina outer nuclear layer	Present	Regionally restricted	1A S opsin -/- (sup)	Expression in cells populating entire outer nuclear layer.

1A S opsin +/+ (inf) ©

Specimen 1A S opsin +/+ (inf): postnatal day 23 (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: retina outer nuclear layer	retinal cone cell	Present	Regionally restricted	1A S opsin +/+ (inf)	Expression in cones at outer edge of outer nuclear layer.

1A S opsin -/- (inf) ©

Specimen 1A S opsin -/- (inf): postnatal day 23; Rorb^tm1Mba/Rorb^tm1Mba (more

)

Structure	Level	Pattern	Image	Note
TS28: retina outer nuclear layer	Strong	Graded	1A S opsin -/- (inf)	Expression in cells populating entire outer nuclear layer.
TS28: retina inner nuclear layer	Trace	Single cells	1A S opsin -/- (inf)	Expression in a few displaced cells in inner nuclear layer.

1B +/+ P6 ©

Specimen 1B +/+ P6: postnatal day 6 (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: retina outer nuclear layer	retinal cone cell	Present	Regionally restricted	1B +/+ P6	Expression in cones at outer edge of outer nuclear layer.

1B +/+ P9 ©

Specimen 1B +/+ P9: postnatal day 9 (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: retina outer nuclear layer	retinal cone cell	Present	Regionally restricted	1B +/+ P9	Expression in cones migrating across outer nuclear layer toward inner nuclear layer.

1B +/+ P14 ©

Specimen 1B +/+ P14: postnatal day 14 (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: retina outer nuclear layer	retinal cone cell	Present	Regionally restricted	1B +/+ P14	Expression in cones at outer edge of outer nuclear layer.

1B -/- P6 ©

Specimen 1B -/- P6: postnatal day 6; Rorb^tm1Mba/Rorb^tm1Mba (more

)

Structure	Level	Pattern	Image	Note
TS28: retina outer nuclear layer	Absent		1B -/- P6

1B -/- P9 ©

Specimen 1B -/- P9: postnatal day 9; Rorb^tm1Mba/Rorb^tm1Mba (more

)

Structure	Level	Pattern	Image	Note
TS28: retina outer nuclear layer	Trace		1B -/- P9

1B -/- P14 ©

Specimen 1B -/- P14: postnatal day 14; Rorb^tm1Mba/Rorb^tm1Mba (more

)

Structure	Level	Pattern	Image	Note
TS28: retina outer nuclear layer	Strong		1B -/- P14	Overexpression occurred between P9 and P14.

Specimen 3C S opsin +/+: postnatal day 31 (more

)

Structure	Level	Pattern	Image	Note
TS28: retina outer nuclear layer	Weak		3C S opsin +/+

Specimen 3C S opsin -/-: postnatal day 31; Rorb^tm1Mba/Rorb^tm1Mba (more

)

Structure	Level	Pattern	Image	Note
TS28: retina outer nuclear layer	Strong		3C S opsin -/-

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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