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Gene Expression Data
Assay Details
Assay
Reference: J:328858 Poeta L, et al., Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders. Hum Mol Genet. 2019 Dec 15;28(24):4089-4102
Assay type: RT-PCR
MGI Accession ID: MGI:7781701
Gene symbol: Kdm5c
Gene name: lysine demethylase 5C
Probe: Kdm5c-pF, Kdm5c-pR
Probe preparation: labelled with SYBR green
Assay notes: Quantitative RT-PCR. Relative expression was normalized to Gapdh and 18S.
Results Image: S4B
 Sample Information Bands Other Sample Information
Lane AgeStructure Size Not Specified Amount Genetic BackgroundMutant Allele(s)Sex
OB WT P0 TS27: main olfactory bulb Present Not Specified; total RNA Not Specified Male
OB Arx-/Y P0 TS27: main olfactory bulb Present (a) Not Specified; total RNA involves: 129/Sv * C57BL/6 Arxtm1Pgr/YMale
CX WT P0 TS27: cerebral cortex Present Not Specified; total RNA Not Specified Male
CX Arx-/Y P0 TS27: cerebral cortex Present (b) Not Specified; total RNA involves: 129/Sv * C57BL/6 Arxtm1Pgr/YMale
STR WT P0 TS27: corpus striatum Present Not Specified; total RNA Not Specified Male
STR Arx-/Y P0 TS27: corpus striatum Present (c) Not Specified; total RNA involves: 129/Sv * C57BL/6 Arxtm1Pgr/YMale
HP WT P0 TS27: hippocampus Present Not Specified; total RNA Not Specified Male
HP Arx-/Y P0 TS27: hippocampus Present (d) Not Specified; total RNA involves: 129/Sv * C57BL/6 Arxtm1Pgr/YMale
TH + HY WT P0 TS27: hypothalamus
TS27: thalamus 		Present Not Specified; total RNA Not Specified Male
TH + HY Arx-/Y P0 TS27: hypothalamus
TS27: thalamus 		Present (e) Not Specified; total RNA involves: 129/Sv * C57BL/6 Arxtm1Pgr/YMale
Notes:
(a) There is a 63% decrease in expression compared to wild-type.
(b) There is a 40% decrease in expression compared to wild-type.
(c) There is a 42% decrease in expression compared to wild-type.
(d) There is a 60% decrease in expression compared to wild-type.
(e) There is a 45% decrease in expression compared to wild-type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory