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Gene Expression Data
Assay Details
Assay
Reference: J:125903 Dominguez MG, et al., Vascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3243-8
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:7780059
Gene symbol: Ptprb
Gene name: protein tyrosine phosphatase receptor type B
Reporter: lacZ
Direct Detection
Results
Specimen 4A: embryonic day 10.5; Ptprbtm1Gdy/Ptprb+ (more )
Structure Level Pattern Image Note
TS17: dorsal aorta endothelium Strong 4A
TS17: umbilical artery Strong 4A
TS17: blood vessel endothelium Strong Widespread 4A The reporter was strongly expressed in the endothelium of vessels of all sizes, including arteries, capillaries, and somewhat more lightly in veins.
Specimen 4B: embryonic day 10.5; Ptprbtm1Gdy/Ptprb+ (more )
Structure Level Pattern Image Note
TS17: blood vessel endothelium Strong Widespread 4B In the head vasculature, the reporter was strongly expressed in the endothelium of vessels of all sizes, including arteries, capillaries, and somewhat more lightly in veins.
Specimen 4C: embryonic day 10.5; Ptprbtm1Gdy/Ptprb+ (more )
Structure Level Pattern Image Note
TS17: heart endothelium Strong 4C
TS17: aortic sac Strong 4C
TS17: atrioventricular canal Strong 4C
TS17: dorsal aorta endothelium Strong 4C
TS17: outflow tract endothelium Strong 4C
TS17: blood vessel endothelium Strong Widespread 4C The reporter was strongly expressed in the endothelium of vessels of all sizes, including arteries, capillaries, and somewhat more lightly in veins.
TS17: cardinal vein Present 4C Lower expression was observed.
Specimen 4D: embryonic day 10.5; Ptprbtm1Gdy/Ptprb+ (more )
Structure Level Pattern Image Note
TS17: aortic sac Strong 4D
TS17: atrioventricular canal Strong 4D
TS17: heart endothelium Strong 4D
TS17: dorsal aorta endothelium Strong 4D
TS17: outflow tract endothelium Strong 4D
TS17: 3rd arch artery Strong 4D
TS17: anterior cardinal vein Present 4D Lower expression was observed.
Specimen 4E: embryonic day 10.5; Ptprbtm1Gdy/Ptprb+ (more )
Structure Level Pattern Image Note
TS17: dorsal aorta endothelium Strong 4E
TS17: cardinal vein Present 4E Lower expression was observed.
Specimen 4F: embryonic day 15.5; Ptprbtm1Gdy/Ptprb+ (more )
Structure Level Pattern Image Note
TS23: venous blood vessel Present 4F Lower expression was observed.
TS23: arterial blood vessel Strong 4F Expression was higher in arteries.
TS23: vascular element Present Regionally restricted 4F Expression was detected in arterioles and venules of organs.
Specimen 5E: embryonic day 15.5; Ptprbtm1Gdy/Ptprb+ (more )
Structure Level Pattern Image Note
TS23: heart valve Strong 5E
Specimen 5F: embryonic day 15.5; Ptprbtm1Gdy/Ptprb+ (more )
Structure Level Pattern Image Note
TS23: heart valve Strong 5F
Specimen not shown: embryonic day 9.5; Ptprbtm1Gdy/Ptprb+ (more )
Structure Level Pattern Image Note
TS15: aortic sac Present Highest sites of expression.
TS15: dorsal aorta Present Highest sites of expression.
TS15: outflow tract Present Highest sites of expression.
TS15: umbilical artery Present Highest sites of expression.
TS15: blood vessel Present Non-Uniform Weak or limited expression was noted in smaller-caliber vessels.
Specimen not shown: embryonic day 10.5; Ptprbtm1Gdy/Ptprb+ (more )
Structure Level Pattern Image Note
TS17: vitelline blood vessel Present Regionally restricted Expression was detected in the vitelline vessels of the yolk sac.
Specimen not shown: postnatal adult; Ptprbtm1Gdy/Ptprb+ (more )
Structure Level Pattern Image Note
TS28: heart valve Strong
TS28: lung vascular element Strong
TS28: renal vasculature Strong
TS28: spleen vascular element Strong
TS28: arteriole endothelium Present
TS28: venule endothelium Present
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory