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Gene Expression Data
Assay Details
Assay
Reference: J:235368 Gomez-Del Arco P, et al., The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis. Cell Metab. 2016 May 10;23(5):881-92
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7750786
Gene symbol: Hnf4a
Gene name: hepatic nuclear factor 4, alpha
Antibody: Anti-Tnf4
Results
Specimen S5A WT: postnatal week 8 (more )
Note: Double labeled: red - Hnf4a; green - alpha-actinin.
Structure Cell Type Level Pattern Image Note
TS28: heart fibroblast Present Single cells S5A WT right , S5A WT center Expression was detected in interstitial fibroblast cells.
Specimen S5A Chd4corin top: postnatal week 8; Chd4tm1.1Kge/Chd4tm1.1Kge, Corintm2(cre)Bamo/Corintm2(cre)Bamo (more )
Note: Conditional mutant. Double labeled: red - Hnf4a; green - alpha-actinin.
Structure Cell Type Level Pattern Image Note
TS28: heart fibroblast Present Regionally restricted S5A Chd4corin top center , S5A Chd4corin top right Chd4 mutant hearts present more fibrotic cells than wild type, but these Hnf4a-expressing cells do not express the cardiomyocyte marker a-actinin.
Specimen S5A Chd4corin middle: postnatal week 8; Chd4tm1.1Kge/Chd4tm1.1Kge, Corintm2(cre)Bamo/Corintm2(cre)Bamo (more )
Note: Conditional mutant. Double labeled: red - Hnf4a; green - alpha-actinin.
Structure Cell Type Level Pattern Image Note
TS28: heart fibroblast Present Regionally restricted S5A Chd4corin middle center , S5A Chd4corin middle right Chd4 mutant hearts present more fibrotic cells than wild type, but these Hnf4a-expressing cells do not express the cardiomyocyte marker a-actinin.
Specimen S5A Chd4corin bottom: postnatal week 8; Chd4tm1.1Kge/Chd4tm1.1Kge, Corintm2(cre)Bamo/Corintm2(cre)Bamo (more )
Note: Conditional mutant. Double labeled: red - Hnf4a; green - alpha-actinin.
Structure Cell Type Level Pattern Image Note
TS28: heart fibroblast Present Regionally restricted S5A Chd4corin bottom right , S5A Chd4corin bottom center Chd4 mutant hearts present more fibrotic cells than wild type, but these Hnf4a-expressing cells do not express the cardiomyocyte marker a-actinin.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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