Gene Expression Data
Assay Details
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Assay
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Reference:
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J:49434
Farinas I, et al., Characterization of neurotrophin and Trk receptor functions in developing sensory ganglia: direct NT-3 activation of TrkB neurons in vivo. Neuron. 1998 Aug;21(2):325-34
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Assay type:
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Immunohistochemistry
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MGI Accession ID:
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MGI:7735226
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Gene symbol:
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Ntrk1
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Gene name:
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neurotrophic tyrosine kinase, receptor, type 1
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Antibody:
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rtrkA.EX2
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Detection system:
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Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase
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Results
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Specimen
1A:
embryonic day 11.0
(more  )
Note: Summarized in Table 1.
Specimen
1A:
(close  )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 11.0
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Age Note:
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Age of embryo at noon of plug day not specified in reference.
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Sex:
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Not Specified
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Type:
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section
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Note:
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Summarized in Table 1.
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| Structure |
Level |
Pattern |
Image |
Note |
| TS18: dorsal root ganglion |
Present |
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1A
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Expressed in both intracellular and surface membrane compartments in axons as well as cell bodies of neurons. The average sizes of positive neurons appeared to be significantly smaller than those of neurons expressing either Ntrk2 or Ntrk3.
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Specimen
1B:
embryonic day 13.0
(more )
Note: Summarized in Table 1.
Specimen
1B:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 13.0
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Age Note:
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Age of embryo at noon of plug day not specified in reference.
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Sex:
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Not Specified
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Type:
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section
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Note:
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Summarized in Table 1.
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| Structure |
Level |
Pattern |
Image |
Note |
| TS21: dorsal root ganglion |
Present |
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1B
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Expressed in both intracellular and surface membrane compartments in axons as well as cell bodies of neurons. The numbers of positive cells dramatically increased. Expressed in vast majority of neurons.
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Specimen
not shown:
embryonic day 12.0
(more )
Note: Summarized in Table 1.
Specimen
not shown:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 12.0
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Age Note:
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Age of embryo at noon of plug day not specified in reference.
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Sex:
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Not Specified
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Type:
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section
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Note:
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Summarized in Table 1.
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| Structure |
Level |
Pattern |
Image |
Note |
| TS20: dorsal root ganglion |
Present |
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Expressed in both intracellular and surface membrane compartments in axons as well as cell bodies of neurons. Increased number of positive neurons.
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Specimen
3A:
embryonic day 11.0
(more )
Specimen
3A:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 11.0
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Age Note:
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Age of embryo at noon of plug day not specified in reference.
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS18: dorsal root ganglion |
Present |
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3A
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Positive cells had a clear neuronal morphology with the bipolar shape characteristic of young sensory neurons.
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Specimen
5E:
(close )
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Genetic Background:
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involves: 129S2/SvPas
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Mutant Allele(s):
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Ntf3tm1Lfr/Ntf3tm1Lfr
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Age:
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embryonic day 11.0
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Age Note:
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Age of embryo at noon of plug day not specified in reference.
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Sex:
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Not Specified
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Type:
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section
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Note:
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Summarized in Table 2.
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| Structure |
Level |
Pattern |
Image |
Note |
| TS18: dorsal root ganglion |
Present |
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5E
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Positive neurons appeared to be completely normal, never associated with pyknotic profiles. The total number of positive neurons was not reduced in the mutant.
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Specimen
not shown:
embryonic day 9.0
(more )
Specimen
not shown:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 9.0
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Age Note:
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Age of embryo at noon of plug day not specified in reference.
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Sex:
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Not Specified
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Type:
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section
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Specimen
not shown:
embryonic day 10.0
(more )
Specimen
not shown:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 10.0
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Age Note:
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Age of embryo at noon of plug day not specified in reference.
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS16: dorsal root ganglion |
Present |
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The number of positive cells increased in the caudal-to-rostral direction.
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