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Gene Expression Data
Assay Details
Assay
Reference: J:44286 Liebl DJ, et al., Absence of sensory neurons before target innervation in brain-derived neurotrophic factor-, neurotrophin 3-, and TrkC-deficient embryonic mice. J Neurosci. 1997 Dec 1;17(23):9113-21
Assay type: RNA in situ
MGI Accession ID: MGI:7734683
Gene symbol: Ntrk2
Gene name: neurotrophic tyrosine kinase, receptor, type 2
Probe: TrkB probe
Probe preparation: Antisense labelled with S35 RNA
Results
Specimen 2Aa: postnatal newborn (more )
Structure Cell Type Level Pattern Image Note
TS27: trigeminal ganglion trigeminal neuron Present 2Aa In wild-type trigeminal ganglion, ~28% of the neurons express Ntrk2.
Specimen 2Ab: postnatal newborn; Bdnftm1Par/Bdnftm1Par (more )
Structure Cell Type Level Pattern Image Note
TS27: trigeminal ganglion trigeminal neuron Present Regionally restricted 2Ab The trigeminal ganglia of BDNF mutant mice have an ~20% neuron reduction, which represents about half of the Ntrk2-expressing neurons.
Specimen 2Ac: postnatal newborn; Ntf3tm1Par/Ntf3tm1Par (more )
Structure Cell Type Level Pattern Image Note
TS27: trigeminal ganglion trigeminal neuron Present Regionally restricted 2Ac A significant reduction in the number of Ntrk2-expressing neurons was observed in NT-3 mutant ganglia.
Specimen 2Ad: postnatal newborn; Bdnftm1Par/Bdnftm1Par, Ntf3tm1Par/Ntf3tm1Par (more )
Structure Cell Type Level Pattern Image Note
TS27: trigeminal ganglion trigeminal neuron Weak Regionally restricted 2Ad A small proportion of Ntrk2-expressing neurons persists in the DKO (BDNF/NT-3-/-).
Specimen 2Bi: postnatal newborn (more )
Structure Cell Type Level Pattern Image Note
TS27: dorsal root ganglion peripheral nervous system neuron Present Regionally restricted 2Bi In wild-type dorsal root ganglion ~8% of the neurons express Ntrk2.
Specimen 2Bj: postnatal newborn; Bdnftm1Par/Bdnftm1Par (more )
Structure Cell Type Level Pattern Image Note
TS27: dorsal root ganglion peripheral nervous system neuron Present Regionally restricted 2Bj A significant reduction in the number of Ntrk2-expressing neurons was observed in BDNF mutant ganglia.
Specimen 2Bk: postnatal newborn; Ntf3tm1Par/Ntf3tm1Par (more )
Structure Cell Type Level Pattern Image Note
TS27: dorsal root ganglion peripheral nervous system neuron Present Regionally restricted 2Bk A significant reduction in the number of Ntrk2-expressing neurons was observed in NT-3 mutant ganglia.
Specimen 2Bl: postnatal newborn; Bdnftm1Par/Bdnftm1Par, Ntf3tm1Par/Ntf3tm1Par (more )
Structure Cell Type Level Pattern Image Note
TS27: dorsal root ganglion peripheral nervous system neuron Weak Regionally restricted 2Bl A small proportion of Ntrk2-expressing neurons persists in the DKO.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory