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Gene Expression Data
Assay Details
Assay
Reference: J:333283 Guan N, et al., Disruption of mitochondrial complex III in cap mesenchyme but not in ureteric progenitors results in defective nephrogenesis associated with amino acid deficiency. Kidney Int. 2022 Jul;102(1):108-120
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7718701
Gene symbol: Lrp2
Gene name: low density lipoprotein receptor-related protein 2
Results
Specimen 2a Cre-: postnatal day 0; Uqcrqtm1.1Ncdl/Uqcrqtm1.1Ncdl (more )
Structure Level Pattern Image Note
TS27: nephron Present 2a Megalin left
Specimen 2a Six2-Qpc-/-: postnatal day 0; Tg(Six2-EGFP/cre)1Amc/0, Uqcrqtm1.1Ncdl/Uqcrq+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: nephron Present 2a Megalin right Significantly reduced expression compared with the control.
Specimen S2 Cre-: embryonic day 15.5; Uqcrqtm1.1Ncdl/Uqcrqtm1.1Ncdl (more )
Note: Double labeled: red - Lrp2; green - pan-cytokeratin.
Structure Level Pattern Image Note
TS23: nephron Present S2_Megalin left
Specimen S2 Six2-Qpc-/-: embryonic day 15.5; Tg(Six2-EGFP/cre)1Amc/0, Uqcrqtm1.1Ncdl/Uqcrq+ (more )
Note: Conditional mutant. Double labeled: red - Lrp2; green - pan-cytokeratin.
Structure Level Pattern Image Note
TS23: nephron Weak S2_Megalin right Significantly reduced expression compared with the control.
Specimen S4 Cre-: postnatal day 0; Uqcrqtm1.1Ncdl/Uqcrqtm1.1Ncdl (more )
Structure Level Pattern Image Note
TS27: nephron Present S4C Megalin left
Specimen S4 Hoxb7-Qpc-/-: postnatal day 0; Tg(Hoxb7-cre)13Amc/0, Uqcrqtm1.1Ncdl/Uqcrqtm1.1Ncdl (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: nephron Present S4C Megalin right Similar as the control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory