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Gene Expression Data
Assay Details
Assay
Reference: J:62595 Jacquemin P, et al., Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3. Mol Cell Biol. 2000 Jun;20(12):4445-54
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7718630
Gene symbol: Gcg
Gene name: glucagon
Antibody: anti-GLU 001
Detection system: Secondary antibody
Results
Specimen 3A: postnatal week 5 (more )
Note: Genetic background of control was either wild type or heterozygous. Double labeled: green - Gcg; red - Ins1 (assay MGI:7718634) and Ins2 (assay MGI:7718635).
Structure Level Pattern Image Note
TS28: pancreatic islet mantle Present Regionally restricted 3A Mantle of Gcg-expressing cells around insulin-expressing cells.
Specimen 3B: postnatal week 5; Onecut1tm1Flem/Onecut1tm1Flem (more )
Note: Double labeled: green - Gcg; red - Ins1 (assay MGI:7718634) and Ins2 (assay MGI:7718635).
Structure Level Pattern Image Note
TS28: islets of Langerhans Present Regionally restricted 3B Islets with perturbed architecture. No mantle of Gcg-expressing cells around insulin-expressing cells. Expression in a few cells in epithelium of cysts.
Specimen not shown: postnatal week 10; Onecut1tm1Flem/Onecut1tm1Flem (more )
Structure Cell Type Level Pattern Image Note
TS28: islets of Langerhans pancreatic A cell Present Scattered Expression in alpha cells scattered throughout islets.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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