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Gene Expression Data
Assay Details
Assay
Reference: J:132157 Nakamura T, et al., Transcription factor epiprofin is essential for tooth morphogenesis by regulating epithelial cell fate and tooth number. J Biol Chem. 2008 Feb 22;283(8):4825-33
Assay type: RNA in situ
MGI Accession ID: MGI:7712008
Gene symbol: Lef1
Gene name: lymphoid enhancer binding factor 1
Probe: Lef1 probe
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 6A: embryonic day 11.5; Sp6tm1Yoya/Sp6+ (more )
Structure Level Pattern Image Note
TS19: dental placode Present 6A
TS19: mandibular process ectoderm Present 6A
TS19: mandibular process mesenchyme Present 6A
TS19: maxillary process ectoderm Present 6A
TS19: maxillary process mesenchyme Present 6A
Specimen 6B: embryonic day 14.5; Sp6tm1Yoya/Sp6+ (more )
Structure Level Pattern Image Note
TS22: enamel knot Present 6B
TS22: molar mesenchyme Present 6B Expression is in the mesenchyme surrounding the enamel knot.
Specimen 6E: embryonic day 11.5; Sp6tm1Yoya/Sp6tm1Yoya (more )
Structure Level Pattern Image Note
TS19: dental placode Strong 6E
TS19: mandibular process ectoderm Strong 6E
TS19: mandibular process mesenchyme Strong 6E
TS19: maxillary process ectoderm Strong 6E
TS19: maxillary process mesenchyme Strong 6E
Specimen 6F: embryonic day 14.5; Sp6tm1Yoya/Sp6tm1Yoya (more )
Structure Level Pattern Image Note
TS22: molar epithelium Strong Regionally restricted 6F In this mutant expression extended into the inner dental epithelium layer compared to controls.
TS22: molar mesenchyme Strong Regionally restricted 6F Expression is in the mesenchyme surrounding the enamel knot.
TS22: enamel knot Absent 6F
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory