Sst RNA in situ Gene Expression Assay

Gene Expression Data
Assay Details

Assay

Reference:	J:269929 Elbert A, et al., CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons. J Neurosci. 2019 Jan 2;39(1):177-192
Assay type:	RNA in situ
MGI Accession ID:	MGI:7711359
Gene symbol:	Sst
Gene name:	somatostatin

Probe:	Sst probe
Probe preparation:	Antisense labelled with digoxigenin RNA
Visualized with:	Alkaline phosphatase

Results

2C control ©

Specimen 2C control: embryonic day 13.5 (more

)

Structure	Level	Pattern	Image	Note
TS21: telencephalon	Present		2C control

2C cKO ©

Specimen 2C Ctcf Nes-Cre: embryonic day 13.5; Ctcf^tm2Gal/Ctcf^tm2Gal, Tg(Nes-cre)2472Pick/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS21: telencephalon	Present	Regionally restricted	2C cKO	Fewer positive cells migrating tangentially from the medial ganglionic eminence toward the cortex in the mutant compared with control embryos.

2E Puma-/- ©

Specimen 2E Puma-/-: embryonic day 13.5; Bbc3^tm1Ast/Bbc3^tm1Ast (more

)

Structure	Level	Pattern	Image	Note
TS21: telencephalon	Present		2E Puma-/-

Specimen 2E Ctcf Nes-Cre;Puma-/-: embryonic day 13.5; Bbc3^tm1Ast/Bbc3^tm1Ast, Ctcf^tm2Gal/Ctcf^tm2Gal, Tg(Nes-cre)2472Pick/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS21: telencephalon	Present	Regionally restricted	2E cKO;Puma-/-	Fewer positive cells migrating tangentially from the medial ganglionic eminence toward the cortex in the mutant compared with control embryos. Preventing apoptosis of cells via removal of PUMA/Bbc3 failed to rescue the change.

5D control ©

Specimen 5D control: embryonic day 13.5 (more

)

Structure	Level	Pattern	Image	Note
TS21: telencephalon	Present		5D control

5D cKO ©

Specimen 5D Ctcf Nkx-Cre: embryonic day 13.5; Ctcf^tm2Gal/Ctcf^tm2Gal, Tg(Nkx2-1-cre)2Sand/0 (more

)
Note: Conditional mutant.

Structure	Level	Pattern	Image	Note
TS21: telencephalon	Present	Regionally restricted	5D cKO	Fewer positive cells migrating tangentially from the medial ganglionic eminence toward the cortex in the mutant compared with control embryos.

6F control ©

Specimen 6F control: postnatal day 21 (more

)

Structure	Cell Type	Level	Pattern	Image	Note
TS28: cerebral cortex	cortical interneuron	Present		6F control

6F cKO ©

Specimen 6F Ctcf Nkx-Cre: postnatal day 21; Ctcf^tm2Gal/Ctcf^tm2Gal, Tg(Nkx2-1-cre)2Sand/0 (more

)
Note: Conditional mutant.

Structure	Cell Type	Level	Pattern	Image	Note
TS28: cerebral cortex	cortical interneuron	Present		6F cKO	Significantly reduced number of positive cells compared with controls.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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